Nijmegen/Amsterdam, January 10, 2017
Okklo Life Sciences B.V. and Sanquin sign commercialization agreement to enter IND enabling studies and clinical development.
Okklo Life Sciences B.V. (Nijmegen, The Netherlands) and Sanquin Blood Supply Foundation (Amsterdam, the Netherlands) today announced that they have signed an agreement regarding the further development and commercialization of their first in class pro-haemostatic cyclodextrins.
The agreement covers the (pre-)clinical development and commercialization of several lead compounds in the field of haemostasis. These ring-shaped sugar molecules belong to the class of cyclodextrins, and represent the first non-peptidergic compounds that may be used as pro-coagulants.
Okklo and Sanquin have jointly developed a series of proprietary cyclodextrins that have shown strong pro-haemostatic effects in in vitro and in vivo models of both, anticoagulant reversal and haemophilia. Accordingly, these first in class molecules will now be further developed for the treatment or prevention of acute bleedings (including reversal of anticoagulant effects) and the treatment of bleeding disorders such as haemophilia.
The initial development plan includes the execution of IND-enabling studies and a phase I study. These studies may be performed by Okklo and Sanquin themselves, or in collaboration with a partner. The parties are now actively looking for co-development partners.
For more information, please contact:
Alex Zwiers, Okklo Life Sciences
phone +31 6 1048 9150
Robert Heckert, Sanquin Blood Supply Foundation
phone +31 20 512 3998